TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.
Identifieur interne : 000036 ( Main/Exploration ); précédent : 000035; suivant : 000037TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.
Auteurs : Shamsul Morshed [Japon] ; Tasnuva Sharmin [Japon] ; Takashi Ushimaru [Japon]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2020.
Descripteurs français
- KwdFr :
- Complexes de tri endosomique requis pour le transport (métabolisme), Endosomes (métabolisme), Facteurs de transcription (métabolisme), Membranes intracellulaires (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines à fluorescence verte (métabolisme), Récepteurs cytoplasmiques et nucléaires (métabolisme), Saccharomyces cerevisiae (métabolisme), Transport biologique (MeSH), Transport des protéines (MeSH), Vacuoles (métabolisme).
- MESH :
- métabolisme : Complexes de tri endosomique requis pour le transport, Endosomes, Facteurs de transcription, Membranes intracellulaires, Protéines de Saccharomyces cerevisiae, Protéines à fluorescence verte, Récepteurs cytoplasmiques et nucléaires, Saccharomyces cerevisiae, Vacuoles.
- Transport biologique, Transport des protéines.
English descriptors
- KwdEn :
- Biological Transport (MeSH), Endosomal Sorting Complexes Required for Transport (metabolism), Endosomes (metabolism), Green Fluorescent Proteins (metabolism), Intracellular Membranes (metabolism), Microautophagy (MeSH), Protein Transport (MeSH), Receptors, Cytoplasmic and Nuclear (metabolism), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (metabolism), Transcription Factors (metabolism), Vacuoles (metabolism).
- MESH :
- chemical , metabolism : Endosomal Sorting Complexes Required for Transport, Green Fluorescent Proteins, Receptors, Cytoplasmic and Nuclear, Saccharomyces cerevisiae Proteins, Transcription Factors.
- metabolism : Endosomes, Intracellular Membranes, Saccharomyces cerevisiae, Vacuoles.
- Biological Transport, Microautophagy, Protein Transport.
Abstract
Microautophagy is promoted after nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1) kinase. Invagination of vacuolar membranes by endosomal sorting complex required for transport (ESCRT) is required for microautophagy. Vps27, a subunit of ESCRT-0, is recruited onto vacuolar membranes via dephosphorylation after TORC1 inactivation. Here, we showed that Hse1, another ESCRT-0 subunit, is also recruited onto vacuolar membranes after TORC1 inactivation, promoting formation of ESCRT-0 complex on vacuolar membranes. Hse1 recruitment was dependent on Vps27, whereas Vps27 recruitment was independent of Hse1. Not only Vps27 but also Hse1 was required for ESCRT-III recruitment onto vacuolar membranes and microautophagy induction after TORC1 inactivation. This study revealed that ESCRT-0 (Vps27-Hse1) complex formation on vacuolar membranes is important for microautophagy inactivation after TORC1 inactivation.
DOI: 10.1016/j.bbrc.2019.11.064
PubMed: 31740006
Affiliations:
Links toward previous steps (curation, corpus...)
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Invagination of vacuolar membranes by endosomal sorting complex required for transport (ESCRT) is required for microautophagy. Vps27, a subunit of ESCRT-0, is recruited onto vacuolar membranes via dephosphorylation after TORC1 inactivation. Here, we showed that Hse1, another ESCRT-0 subunit, is also recruited onto vacuolar membranes after TORC1 inactivation, promoting formation of ESCRT-0 complex on vacuolar membranes. Hse1 recruitment was dependent on Vps27, whereas Vps27 recruitment was independent of Hse1. Not only Vps27 but also Hse1 was required for ESCRT-III recruitment onto vacuolar membranes and microautophagy induction after TORC1 inactivation. This study revealed that ESCRT-0 (Vps27-Hse1) complex formation on vacuolar membranes is important for microautophagy inactivation after TORC1 inactivation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31740006</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>522</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>01</Month><Day>29</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.</ArticleTitle><Pagination><MedlinePgn>88-94</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(19)32184-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2019.11.064</ELocationID><Abstract><AbstractText>Microautophagy is promoted after nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1) kinase. Invagination of vacuolar membranes by endosomal sorting complex required for transport (ESCRT) is required for microautophagy. Vps27, a subunit of ESCRT-0, is recruited onto vacuolar membranes via dephosphorylation after TORC1 inactivation. Here, we showed that Hse1, another ESCRT-0 subunit, is also recruited onto vacuolar membranes after TORC1 inactivation, promoting formation of ESCRT-0 complex on vacuolar membranes. Hse1 recruitment was dependent on Vps27, whereas Vps27 recruitment was independent of Hse1. Not only Vps27 but also Hse1 was required for ESCRT-III recruitment onto vacuolar membranes and microautophagy induction after TORC1 inactivation. This study revealed that ESCRT-0 (Vps27-Hse1) complex formation on vacuolar membranes is important for microautophagy inactivation after TORC1 inactivation.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Morshed</LastName><ForeName>Shamsul</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharmin</LastName><ForeName>Tasnuva</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ushimaru</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan. 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